Follow this ABCDE guide to determine if an unusual mole or su.ious spot on your skin may be melanoma. Melanoma pictures for self-examination. A: Asymmetry. B: Border irregularity. C: Color changes. D: Diameter. E: Evolving..Self-exams can help you identify potential skin cancers early, when they can As a general rule, to spot either melanomas or non-melanoma skin cancers such .The Warning Signs of Skin Cancer. Skin cancers -- including melanoma, basal cell carcinoma, and squamous cell carcinoma -- often start as changes to your skin. They can be new growths or precancerous lesions -- changes that are not cancer but could become cancer over time.. - Skin cancer is the most common of all human cancers. easy-to-remember guideline, "ABCDE," is useful for identifying malignant melanoma:..