Finding Mutations in DNA and Proteins Bioinformatics VI University of California Sango About this course: In previous courses in the Specialization, we have discussed how to sequence and compare genomes..Disease gene identification is a process by which scientists identify the mutant genotypes responsible for an inherited genetic disorder. Mutations in these genes can include single nucleotide subs.utions, single nucleotide additions/deletions, deletion of the entire gene, and other genetic abnormalities..If we generate a mutant strain with the desired phenotype, sequence it, and identify 100 mutated genes, our chances of picking a gene that causes the phenotype rise only nominally, to 1 ..Full-Text Paper PDF : Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.
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