A microRNA abbreviated miRNA is a small non-coding RNA molecule containing about 22 nucleotides found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression..Technology IP. InteRNA pursued a new approach to identify the best miRNA candidate/miRNA targets for each disease type considered. The developed miRNA discovery and functional validation platform enabled an unbiased screening approach in R D focusing on the elucidation of the functional roles of individual miRNAs..16 novel miRNAs, coming under 11 miRNA families. It is equally important to identify miRNA targets toess the biological function of miRNA in plants..Messenger RNA mRNA is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression..
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The miRNA targets have all been predicted using MirTarget, which was developed following theysis of thousands of miRNA-target interactions derived from high-throughput sequencing experiments. miRDB contains predicted miRNA targets covering five animal species: human, mouse, rat, dog and chicken ..
39 rows It can quantify the known miRNA expression and identify novel miRNA from .
If the 3'UTR is a target of a miRNA, the reporter transcript stability and/or its translation efficiency will change with variation in functional miRNA concentration. So unlike transcript-only basedays, reporterays help identify effects on both steady state mRNA and protein levels..
RNAPII-transcribed miRNA promoters are generally similar to known mRNA-encoding promoters. About 64 of miRNA promoters have a CpG island within 500 bp. More .